This paper outlines the nature of spiritual healing from Islamic perspectives based upon the writings of early Muslim scholars, the Islamic mystical tradition and a discussion of common traditional Muslim healing practices useful for clinical application. Practical intervention strategies are discussed within an Islamic-based theoretical framework that outlines the four major elements of the human being. These practices include cognitive restructuring using the Qur’an and traditions of Prophet Mohammed, spiritual remedies presented through the repetition of prescribed prayers, invoking blessings upon the Prophet and reflecting upon a behavioral log of daily actions. These spiritually oriented interventions are accompanied by therapy markers for presentation and are categorized into treatments that align to the corresponding human elements of cognition, behavioral inclination or spirituality. Recommendations for professional practice and future research are also offered.